im playin f:nv too :D but haven't gotten very far.
i've gotten a few weird glitches ...
the dogs have eyes that float alongside their heads, just outside their skulls, next to their ears. the sockets are empty. it's freaky looking.
and some wasteland critters seem to enjoy morphing into the landscape while chasing me. some will clip helplessly into the sand, and a few have stretched into crazy looking half-buried polygons.
at first i thought it was from the wild wasteland trait but ... uh no these look like glitches!
other than that, and a few random bandits that seemed to get stuck reloading their weapons forever, it's the same as fallout 3 ... i was expecting more differences, but it's very addictively fun regardless!