What about the Nuzlocke Challenge?
http://www.nuzlocke.com/?p=4
For those of you who don't know, the Nuzlocke Challenge (Or Pokemon: Hard Mode) means following a set of rules:
1.) You can only catch the first critter you see in an area (barring duplicates). If you knock it out, that's it.
2.) When a critter faints - release it. It's dead and gone.
3.) Name everything for the bondingz.
So far, Ruby has done, well, Ruby, and is in the middle of FireRed. I've heard he intends to do a GenIV run afterwards. Possibly. And the artwork improves in the second FireRed arc.
Also, there is Goblin's Nuzlocke challenge which, despite only going up to Cerulean in LeafGreen is worth reading just for the quality of the later artwork.
http://browse.deviantart.com/?qh=§i ... e#/d2syku3