Yes there is a topic on how to get RMXP to run in vista, but I have taken it a step further and made a Video Tutorial. I uploaded it on You Tube so if your connection is slow, just click the "Puase" button untill it loads some what. Now there is one already on You Tube, but it does not go in much detail. And as you all know dealing with newbies you need detail so enjoy:
RMXP In Vista
RMXP In Vista